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Article

Known mutator alleles do not markedly increase mutation rate in clinical Saccharomyces cerevisiae strains.

Proceedings. Biological sciences - 12 Apr 2017

Skelly Daniel A, Magwene Paul M, Meeks Brianna, Murphy Helen A

Abstract excerpt

Natural selection has the potential to act on all phenotypes, including genomic mutation rate. Classic evolutionary theory predicts that in asexual populations, mutator alleles, which cause high mutation rates, can fix due to linkage with beneficial mutations. This phenomenon has been demonstrated experimentally and may explain the frequency of mutators found in bacterial pathogens. By contrast, in sexual...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28404772
DOI: 10.1098/rspb.2016.2672
PMCID: PMC5394658

Genes

MLH1
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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