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Article

DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae.

Genetics - 1 Apr 1998

Kunz B A, Ramachandran K, Vonarx E J

Abstract excerpt

To help elucidate the mechanisms involved in spontaneous mutagenesis, DNA sequencing has been applied to characterize the types of mutation whose rates are increased or decreased in mutator or antimutator strains, respectively. Increased spontaneous mutation rates point to malfunctions in genes that normally act to reduce spontaneous mutation, whereas decreased rates are associated with defects in genes whose...

Topics

Alleles
Animals
Base Composition
DNA Damage
DNA Polymerase III
DNA Repair
DNA Replication
DNA, Fungal
Humans
Ligases
Mutagenesis
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Sequence Analysis, DNA

Ubiquitin-Conjugating Enzymes

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Identifiers

PMID: 9560369
DOI: 10.1093/genetics/148.4.1491
PMCID: PMC1460101

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