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Article

Mismatch Repair Incompatibilities in Diverse Yeast Populations.

Genetics - 1 Apr 2017

Bui Duyen T, Friedrich Anne, Al-Sweel Najla, Liti Gianni, Schacherer Joseph, Aquadro Charles F, Alani Eric

Abstract excerpt

An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, created through mating between divergent S. cerevisiae, yields mutator progeny that can rapidly but...

Topics

DNA Mismatch Repair
Evolution, Molecular
Genetic Background
Genetic Fitness
Homozygote
MutL Protein Homolog 1
MutL Proteins
Mutation Rate
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 28193730
DOI: 10.1534/genetics.116.199513
PMCID: PMC5378106

Genes

MLH1
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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