Article

Multiplexing Mutation Rate Assessment: Determining Pathogenicity of Msh2 Variants in <i>S. cerevisiae</i>

2020-10-05

Abstract excerpt

Despite the fundamental importance of mutation rate as a driving force in evolution and disease risk, common methods to assay mutation rate are time consuming and tedious. Established methods such as fluctuation tests and mutation accumulation experiments are low-throughput and often require significant optimization to ensure accuracy. We established a new method to determine the mutation rate of many strains simu...

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Literature Corpus work: 9951b187-9044-5aa2-a7b6-89352674828b
DOI: 10.1101/2020.10.05.325902

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