Article
Ploidy controls the success of mutators and nature of mutations during budding yeast evolution.
Current biology : CB - 22 Aug 2006
Thompson Dawn A, Desai Michael M, Murray Andrew W
Abstract excerpt
BACKGROUND: We used the budding yeast Saccharomyces cerevisiae to ask how elevated mutation rates affect the evolution of asexual eukaryotic populations. Mismatch repair defective and nonmutator strains were competed during adaptation to four laboratory environments (rich medium, low glucose, high salt, and a nonfermentable carbon source). RESULTS: In diploids, mutators have an advantage over nonmutators in all...
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