Article

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

2025-09-04

Abstract excerpt

Dietary protein is a key regulator of metabolic health in humans and rodents. Many of the benefits of protein restriction are mediated by reduced intake of dietary branched-chain amino acids (BCAAs; leucine, valine and isoleucine), and restriction of the BCAAs is sufficient to extend healthspan and lifespan in mice. While the BCAAs have often been considered as a group, it has become apparent that they have distin...

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Literature Corpus work: 63b884ac-e8f7-51ee-b7e7-2222a94686ba
DOI: 10.1101/2025.08.31.673254

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