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A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

26 Feb 2014

Abstract excerpt

Dietary methionine restriction (MR) and calorie restriction (CR) each improve metabolic health and extend life span. We used comprehensive transcriptome profiling and systems biology analysis to interrogate the unique and overlapping molecular responses in rats provided these dietary regimens for 20 mo after weaning. Microarray analysis was conducted on inguinal white adipose (IWAT), brown adipose tissue (BAT),...

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PMID: 24571921
DOI: 10.1096/fj.14-249458

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