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Article

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

PloS one - 1 Jan 2015

Barger Jamie L, Anderson Rozalyn M, Newton Michael A, da Silva Cristina, Vann James A, Pugh Thomas D, Someya Shinichi, Prolla Tomas A, Weindruch Richard

Abstract excerpt

Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerab...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25830335
DOI: 10.1371/journal.pone.0120738
PMCID: PMC4382298

Genes

SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25830335-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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