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Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner

16 Apr 2025

Abstract excerpt

Aging is associated with dysregulated methionine metabolism and increased levels of enzymes in the tyrosine degradation pathway (TDP). To investigate the efficacy of targeting either methionine metabolism or the TDP for healthspan improvement in advanced age, we initiated dietary MetR or TDP inhibition in 18-month-old C57BL/6J mice. MetR significantly improved neuromuscular function, metabolic health, lung...

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PMID: 40238871
DOI: 10.1126/sciadv.ads1532

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