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Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

30 Apr 2011

Abstract excerpt

Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms - increased mitochondrial respiration...

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PMID: 21566257
DOI: 10.18632/aging.100322

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