Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.

Experimental gerontology - 1 Jul 2013

Perrone Carmen E, Malloy Virginia L, Orentreich David S, Orentreich Norman

Abstract excerpt

Restriction of dietary methionine by 80% slows the progression of aged-related diseases and prolongs lifespan in rodents. A salient feature of the methionine restriction phenotype is the significant reduction of adipose tissue mass, which is associated with improvement of insulin sensitivity. These beneficial effects of MR involve a host of metabolic adaptations leading to increased mitochondrial biogenesis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet
Share to Adaptation, Physiological
Share to Adiposity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Insulin Resistance

Share to Methionine

Share to Oxidative Stress

Share to Rodentia

Source

Identifiers

PMID: 22819757
DOI: 10.1016/j.exger.2012.07.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.PMID 22819757Read ↗

Physiological and Molecular Mechanisms of Methionine RestrictionSemantic proximity Read ↗

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.Semantic proximity Read ↗

Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-DependentSemantic proximity Read ↗

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to miceSemantic proximity Read ↗

Mitochondrial Metabolic Reprogramming Induced by Calorie RestrictionSemantic proximity Read ↗

Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.Semantic proximity Read ↗

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in ratsSemantic proximity Read ↗

The fine line between lifespan extension and shortening in response to caloric restrictionSemantic proximity Read ↗

Calorie restriction as an intervention in ageingSemantic proximity Read ↗

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in miceSemantic proximity Read ↗

Short‐term methionine deprivation improves metabolic health via sexually dimorphic, mTORCI‐independent mechanismsSemantic proximity Read ↗

Energy restriction and agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.