Article

Deep Profiling of EV Long RNAs Reveals Biofluid-Specific Transcriptomes and Splicing Landscapes

2025-08-05

Abstract excerpt

RNA profiling of extracellular vesicles (EVs) from human biofluids has historically been limited to small RNA species, with long RNAs—such as mRNA exons and long non-coding RNAs—remaining largely underexplored. Moreover, the dominance of hematopoietic-derived EVs in complex fluids like plasma has posed significant challenges for detecting low-abundance, tissue-specific transcripts. Here, we establish foundational...

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Literature Corpus work: 547b0fe5-7daf-5772-87ec-deb37929d922
DOI: 10.1101/2025.08.05.668716

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