Article
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature - 1 Dec 2023
Xu Zheng, Guo Lulu, Yu Jingjing, Shen Siyuan, Wu Chao, Zhang Weifeng, Zhao Chang, Deng Yue, Tian Xiaowen, Feng Yuying, Hou Hanlin, Su Lantian, Wang Hongshuang, Guo Shuo, Wang Heli, Wang Kexin, Chen Peipei, Zhao Jie, Zhang Xiaoyu, Yong Xihao, Cheng Lin, Liu Lunxu, Yang Shengyong, Yang Fan, Wang Xiaohui, Yu Xiao, Xu Yunfei, Sun Jin-Peng, Yan Wei, Shao Zhenhua
Abstract excerpt
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have essential roles in neurological and metabolic homeostasis1. They recognize diverse endogenous trace amines and subsequently activate a range of G-protein-subtype signalling pathways2,3. Notably, TAAR1 has emerged as a promising therapeutic target for treating psychiatric disorders4,5. However, the molecular mechanisms underlying...
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