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Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair

31 Aug 2011

Abstract excerpt

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societies with their aging populations. Accumulation of DNA damage has been proposed to contribute to these impairments, but direct proof that DNA damage results in impaired neuronal plasticity and memory is lacking. Here we take advantage of Ercc1(Δ/-) mutant mice, which are impaired in DNA nucleotide excision repair,...

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PMID: 21880916
DOI: 10.1523/jneurosci.1589-11.2011

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