Article
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.
Nature communications - 7 Jun 2018
Bezawork-Geleta Ayenachew, Wen He, Dong LanFeng, Yan Bing, Vider Jelena, Boukalova Stepana, Krobova Linda, Vanova Katerina, Zobalova Renata, Sobol Margarita, Hozak Pavel, Novais Silvia Magalhaes, Caisova Veronika, Abaffy Pavel, Naraine Ravindra, Pang Ying, Zaw Thiri, Zhang Ping, Sindelka Radek, Kubista Mikael, Zuryn Steven, Molloy Mark P, Berridge Michael V, Pacak Karel, Rohlena Jakub, Park Sunghyouk, Neuzil Jiri
Abstract excerpt
Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CIIlow, serves as a checkpoint for metabolite biosynthesis under bioenergetic stress, with cells suppressing their energy utilization by modulating DNA synthesis and cell cycle progression. Depletion of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.