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Article

The human mitochondrial replication fork in health and disease.

Biochimica et biophysica acta - 1 Aug 2010

Wanrooij Sjoerd, Falkenberg Maria

Abstract excerpt

Mitochondria are organelles whose main function is to generate power by oxidative phosphorylation. Some of the essential genes required for this energy production are encoded by the mitochondrial genome, a small circular double stranded DNA molecule. Human mtDNA is replicated by a specialized machinery distinct from the nuclear replisome. Defects in the mitochondrial replication machinery can lead to loss of...

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PMID: 20417176
DOI: 10.1016/j.bbabio.2010.04.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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