Article

Functional Impact of Nth-like DNA glycosylase on Mitochondrial Dynamics

2024-10-11

Abstract excerpt

<h4>ABSTRACT</h4> NTH-like DNA glycosylase (NTHL1), a key enzyme in the base excision repair (BER) pathway, has long been considered essential for maintaining both nuclear and mitochondrial genome integrity. In this study, we integrate in vitro biochemical assays, in-cellulo molecular biology experiments, and bioinformatic analyses to investigate the impact of NTHL1 loss on mitochondrial DNA (mtDNA) stability a...

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Literature Corpus work: 37cba011-494c-5d9a-b409-25b8e92daed8
DOI: 10.1101/2024.10.10.617535

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