Article

MNRR1 activation by nitazoxanide abrogates lipopolysaccharide-induced preterm birth in mice

2023-02-01

Abstract excerpt

Intra-amniotic inflammation leading to preterm birth is one of the leading causes of neonatal morbidity and mortality. We recently found that the mitochondrial levels of MNRR1 (Mitochondrial Nuclear Retrograde, Regulator 1; also called CHCHD2, AAG10, or PARK22), an important bi-organellar regulator of cellular function, are reduced in the context of inflammation and that both genetic and pharmacological increase i...

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Literature Corpus work: 6374dad7-d47c-5144-906d-c0b8b78087ba
DOI: 10.1101/2023.01.30.525762

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