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Article

Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity.

Scientific reports - 10 Jan 2017

Sussan Thomas E, Sudini Kuladeep, Talbot C Conover, Wang Xiaobin, Wills-Karp Marsha, Burd Irina, Biswal Shyam

Abstract excerpt

Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infants are at increased risk for lifelong disabilities. Intrauterine inflammation is an etiological factor that drives PTB, and oxidative stress is associated with PTB. Nuclear erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that is the key regulator of the response to oxidative and inflammatory stress....

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Identifiers

PMID: 28071748
DOI: 10.1038/srep40194
PMCID: PMC5223218

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