Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Abstract excerpt

<h4>ABSTRACT</h4> Human fetuses with trisomy 21 (T21) have atypical brain development that is apparent sonographically in the second trimester. Prenatal diagnosis provides a potential opportunity to begin treatment in utero . We hypothesize that by analyzing and integrating dysregulated gene expression and pathways common to humans with DS and mouse models we can discover novel targets for therapy. Here, we test...

Topics

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• Brain
• Down-Regulation
• Down Syndrome
• Down syndrome and intellectual disability research
• Neonatal and Maternal Infections
• Neonatal Respiratory Health Research
• Prenatal Screening and Diagnostics
• Preterm Birth and Chorioamnionitis

Identifiers and source

Literature Corpus work

7c20e4b2-e65e-5d26-bca4-467a5853496a

DOI

10.1101/495283