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DDIT4L regulates mitochondrial and innate immune activities in early life

6 Feb 2024

Abstract excerpt

Pattern recognition receptor responses are profoundly attenuated before the third trimester of gestation in the relatively low-oxygen human fetal environment. However, the mechanisms regulating these responses are uncharacterized. Herein, genome-wide transcription and functional metabolic experiments in primary neonatal monocytes linked the negative mTOR regulator DDIT4L to metabolic stress, cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38319716
DOI: 10.1172/jci.insight.172312

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