Article

DRP1 induces neuroinflammation <i>via</i> transcriptional regulation of NF-ĸB

2025-09-06

Abstract excerpt

Neuroinflammation is a major pathogenic mechanism in neurodegenerative diseases. Understanding the regulation of neuroinflammation is critical to therapeutic development. We report here that dynamin related protein 1 (DRP1), well-recognized for its role in mitochondrial fission, is a transcription factor that regulates neuroinflammation. Using multiple inflammatory models, we provide evidence demonstrating that DR...

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Identifiers and source

Literature Corpus work: 95c71151-3b57-548e-a12e-7468aea3354f
DOI: 10.1101/2025.09.02.673863

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