Article

SCReadCounts: Estimation of cell-level SNVs from scRNA-seq data

2020-11-23

Abstract excerpt

Recent studies have demonstrated the utility of scRNA-seq SNVs to distinguish tumor from normal cells, characterize intra-tumoral heterogeneity, and define mutation-associated expression signatures. In addition to cancer studies, SNVs from single cells have been useful in studies of transcriptional burst kinetics, allelic expression, chromosome X inactivation, ploidy estimations, and haplotype inference. To aid th...

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Literature Corpus work: 6339ebac-4356-5e0a-9022-767e8789fe9c
DOI: 10.1101/2020.11.23.394569

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