Article

A wealth of novel cell-specific expressed SNVs from tumor and normal scRNA-seq datasets

2022-06-15

Abstract excerpt

We demonstrate a novel variant calling strategy using barcode-stratified alignments on 25 tumor and normal 10XGenomics scRNA-seq datasets (>200,000 cells). Our approach identified 24,528 exonic non-dbSNP single cell expressed (sce)SNVs, a third of which are shared across multiple samples. The novel sceSNVs include unreported somatic and germline variants, as well as RNA-originating variants; some are expressed in...

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Literature Corpus work: f5e0f0fb-f14d-5377-bd98-73baafa1f39b
DOI: 10.1101/2022.06.12.495797

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