Article
SCReadCounts: estimation of cell-level SNVs expression from scRNA-seq data.
BMC genomics - 22 Sept 2021
Prashant N M, Alomran Nawaf, Chen Yu, Liu Hongyu, Bousounis Pavlos, Movassagh Mercedeh, Edwards Nathan, Horvath Anelia
Abstract excerpt
BACKGROUND: Recent studies have demonstrated the utility of scRNA-seq SNVs to distinguish tumor from normal cells, characterize intra-tumoral heterogeneity, and define mutation-associated expression signatures. In addition to cancer studies, SNVs from single cells have been useful in studies of transcriptional burst kinetics, allelic expression, chromosome X inactivation, ploidy estimations, and haplotype...
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