Article

Identifying cancer cells from calling single-nucleotide variants in scRNA-seq data

2024-02-23

Abstract excerpt

Single cell RNA sequencing (scRNA-seq) data is widely used to study cancer cell states and their heterogeneity. However, the tumour microenvironment is usually a mixture of healthy and cancerous cells and it can be difficult to fully separate these two populations based on transcriptomics alone. If available, somatic single nucleotide variants (SNVs) observed in the scRNA-seq data could be used to identify the can...

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Literature Corpus work: 107e4fbd-0649-5f8b-a117-2b5fb5db73c2
DOI: 10.1101/2024.02.21.581377

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