Article

Improved SNV discovery in barcode-stratified scRNA-seq alignments

2021-06-13

Abstract excerpt

Single cell SNV analysis is an emerging and promising strategy to connect cell-level genetic variation to cell phenotypes. At the present, SNV detection from 10x Genomics scRNA-seq data is typically performed on the pooled sequencing reads across all cells in a sample. Here, we assess the gain of information of SNV assessments from individual cell scRNA-seq data, where the alignments are split by barcode prior to...

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Literature Corpus work: 28bfc0e3-4b05-5111-8210-b12268f23fdd
DOI: 10.1101/2021.06.12.448184

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