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Article

Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data.

Genome biology - 19 Nov 2019

Liu Fenglin, Zhang Yuanyuan, Zhang Lei, Li Ziyi, Fang Qiao, Gao Ranran, Zhang Zemin

Abstract excerpt

BACKGROUND: Systematic interrogation of single-nucleotide variants (SNVs) is one of the most promising approaches to delineate the cellular heterogeneity and phylogenetic relationships at the single-cell level. While SNV detection from abundant single-cell RNA sequencing (scRNA-seq) data is applicable and cost-effective in identifying expressed variants, inferring sub-clones, and deciphering genotype-phenotype...

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Identifiers

PMID: 31744515
DOI: 10.1186/s13059-019-1863-4
PMCID: PMC6862814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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