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The unfolded protein response of the endoplasmic reticulum protects <i>Caenorhabditis elegans</i> against DNA damage caused by stalled replication forks

2023-02-23

Abstract excerpt

All animals must maintain genome and proteome integrity, especially when experiencing endogenous or exogenous stress. To cope, organisms have evolved sophisticated and conserved response systems: unfolded protein responses (UPRs) ensure proteostasis while DNA damage responses (DDRs) maintains genome integrity. Emerging evidence suggests that UPRs and DDRs crosstalk, but this remains poorly understood. Here, we dem...

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Identifiers and source

Literature Corpus work
6338aa71-7891-58fd-897e-d3c548fe4c10
DOI
10.1101/2023.02.23.529758
Open publication

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The unfolded protein response of the endoplasmic reticulum protects <i>Caenorhabditis elegans</i> against DNA damage caused by stalled replication forksDOI 10.1101/2023.02.23.529758
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