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When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

6 Oct 2020

Abstract excerpt

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as...

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PMID: 33036871
DOI: 10.1016/j.tcb.2020.09.002

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