Article
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
Cell - 28 Dec 2001
Shen X, Ellis R E, Lee K, Liu C Y, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit D M, Mori K, Kaufman R J
Abstract excerpt
The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER...
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