Article
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1.
Nucleic acids research - 1 May 2013
Arczewska Katarzyna D, Tomazella Gisele G, Lindvall Jessica M, Kassahun Henok, Maglioni Silvia, Torgovnick Alessandro, Henriksson Johan, Matilainen Olli, Marquis Bryce J, Nelson Bryant C, Jaruga Pawel, Babaie Eshrat, Holmberg Carina I, Bürglin Thomas R, Ventura Natascia, Thiede Bernd, Nilsen Hilde
Abstract excerpt
Transcription-blocking oxidative DNA damage is believed to contribute to aging and to underlie activation of oxidative stress responses and down-regulation of insulin-like signaling (ILS) in Nucleotide Excision Repair (NER) deficient mice. Here, we present the first quantitative proteomic description of the Caenorhabditis elegans NER-defective xpa-1 mutant and compare the proteome and transcriptome signatures....
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