Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer’s disease (AD)

29 Nov 2025

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia affecting 55 million people worldwide. The pathological hallmarks of AD, beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFT), follow distinct stereotypical patterns of progression across brain regions and trigger a multicellular response that ultimately leads to neuronal loss and cognitive decline. Despite the uniform spread of Aβ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurogenesis and neuroplasticity mechanisms
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41318546
DOI: 10.1186/s40246-025-00875-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer’s disease (AD)PMID 41318546Read ↗

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer’s Disease (AD)Semantic proximity Read ↗

Multidimensional Transcriptomics Reveals the Pivotal Role of Neuroinflammation in Alzheimer's DiseaseSemantic proximity Read ↗

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditionsSemantic proximity Read ↗

Distinctive Whole-brain Cell Types Predict Tissue Damage Patterns in Thirteen Neurodegenerative ConditionsSemantic proximity Read ↗

Whole-Brain Cell-Cell Interaction Axes Explaining Tissue Vulnerability Across the Neurodegenerative SpectrumSemantic proximity Read ↗

Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical PracticeSemantic proximity Read ↗

Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.Semantic proximity Read ↗

Applying high-resolution spatial transcriptomics to characterize the amyloid plaque cell niche in Alzheimer’s DiseaseSemantic proximity Read ↗

Spatial Dissection of the Distinct Cellular Responses to Normal Aging and Alzheimer’s Disease in Human Prefrontal Cortex at Single-Nucleus ResolutionSemantic proximity Read ↗

Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s diseaseSemantic proximity Read ↗

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read ↗

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.