Article

STING Beyond Immunity: Tumour-Intrinsic Roles in Breast Cancer Progression and Metastasis

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Purpose Stimulator of Interferon Genes (STING) is a key inducer of type I interferon signalling that promotes immune cell activation and antitumour immune responses. Reduced STING expression has been reported in multiple tumour types, and STING agonists for their purpose of eliciting an anti-tumour immune response, have emerged as a promising strategy in cancer immunotherapy, including...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6328576a-7d36-5c65-b9f7-777a30c5b2c4
DOI: 10.21203/rs.3.rs-9535798/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

STING Beyond Immunity: Tumour-Intrinsic Roles in Breast Cancer Progression and MetastasisDOI 10.21203/rs.3.rs-9535798/v1Read

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.Semantic proximity Read

Expression of the cGAS-STING pathway is associated with high levels of genomic instability and immune cell infiltration in breast cancerSemantic proximity Read

cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancerSemantic proximity Read

The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancerSemantic proximity Read

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage ResponseSemantic proximity Read

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.Semantic proximity Read

Inflammatory Yet Restrained: Context-Dependent STING–Hypoxia Relationships Define Distinct Immune Ecosystems in Glioblastoma Across Bulk, Spatial, and Single-Cell ScalesSemantic proximity Read

MYC promotes immune-suppression in TNBC via inhibition of IFN signalingSemantic proximity Read

Tumour radiosensitivity is associated with immune activation in solid tumours.Semantic proximity Read

MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damageSemantic proximity Read

Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagySemantic proximity Read

STING pathway agonism as a cancer therapeuticSemantic proximity Read