Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.

EBioMedicine - 1 Mar 2024

Tan Jiayi, Egelston Colt A, Guo Weihua, Stark Jeremy M, Lee Peter P

Abstract excerpt

BACKGROUND: While mutation-derived neoantigens are well recognized in generating anti-tumour T cell response, increasing evidences highlight the complex association between tumour mutation burden (TMB) and tumour infiltrating lymphocytes (TILs). The exploration of non-TMB determinants of active immune response could improve the prognosis prediction and provide guidance for current immunotherapy. METHODS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 38401418
DOI: 10.1016/j.ebiom.2024.105035
PMCID: PMC10904200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.PMID 38401418Read ↗

Multiomics and spatial mapping characterizes human CD8 + T cell states in cancerSemantic proximity Read ↗

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read ↗

TERT mutations correlate with higher TMB value and unique tumor microenvironment and may be a potential biomarker for anti-CTLA4 treatment.Semantic proximity Read ↗

The Immune Landscape of CancerSemantic proximity Read ↗

Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burdenSemantic proximity Read ↗

Immunogenomic, single-cell and spatial dissection of CD8 <sup>+</sup> T cell exhaustion reveals critical determinants of cancer immunotherapySemantic proximity Read ↗

Pan-cancer deconvolution of tumour composition using DNA methylation.Semantic proximity Read ↗

STING Beyond Immunity: Tumour-Intrinsic Roles in Breast Cancer Progression and MetastasisSemantic proximity Read ↗

Is tumor mutational burden predictive of response to immunotherapy?Semantic proximity Read ↗

APOBEC3G expression marks a TMB-high, T cell-inflamed tumor state and is associated with response to immune checkpoint blockade in multiple cancer cohortsSemantic proximity Read ↗

Characterization of Exhausted T Cell Signatures in Pan-Cancer SettingsSemantic proximity Read ↗

Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.