Article

Expression of the cGAS-STING pathway is associated with high levels of genomic instability and immune cell infiltration in breast cancer

2023-05-19

Abstract excerpt

<title>Abstract</title> <p>Genomic instability is a hallmark of cancer, and can be caused by oncogene-induced replication stress. Besides driving the evolution of cancer genomes, genomic instability can lead to the activation of inflammatory signaling, involving the cGAS-STING and JAK-STAT pathways. Inflammatory signaling has been associated with pro-tumorigenic features, but has also been associated with favorab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0d3a7ad-1408-51db-9501-9bc73a3a6415
DOI: 10.21203/rs.3.rs-2889818/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression of the cGAS-STING pathway is associated with high levels of genomic instability and immune cell infiltration in breast cancerDOI 10.21203/rs.3.rs-2889818/v1Read

cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancerSemantic proximity Read

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage ResponseSemantic proximity Read

MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damageSemantic proximity Read

STING Beyond Immunity: Tumour-Intrinsic Roles in Breast Cancer Progression and MetastasisSemantic proximity Read

Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder CancerSemantic proximity Read

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.Semantic proximity Read

Chromosomal instability (CIN) triggers immune evasion and metastatic potential in cancer through rewired STING signallingSemantic proximity Read

A genomic instability-related lncRNA model for predicting prognosis and immune checkpoint inhibitor efficacy in breast cancerSemantic proximity Read

The Cytosolic DNA-Sensing cGAS–STING Pathway in CancerSemantic proximity Read

STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal StabilitySemantic proximity Read

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal InstabilitySemantic proximity Read

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcomaSemantic proximity Read