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Article

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2020

Della Corte Carminia M, Sen Triparna, Gay Carl M, Ramkumar Kavya, Diao Lixia, Cardnell Robert J, Rodriguez Bertha Leticia, Stewart C Allison, Papadimitrakopoulou Vassiliki A, Gibson Laura, Fradette Jared J, Wang Qi, Fan Youhong, Peng David H, Negrao Marcelo V, Wistuba Ignacio I, Fujimoto Junya, Solis Soto Luisa M, Behrens Carmen, Skoulidis Ferdinandos, Heymach John V, Wang Jing, Gibbons Don L, Byers Lauren A

Abstract excerpt

INTRODUCTION: Although the combination of anti-programmed cell death-1 or anti-programmed cell death ligand-1 (PD-L1) with platinum chemotherapy is a standard of care for NSCLC, clinical responses vary. Even though predictive biomarkers (which include PD-L1 expression, tumor mutational burden, and inflamed immune microenvironment) are validated for immunotherapy, their relevance to chemoimmunotherapy combinations...

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Identifiers

PMID: 32068166
DOI: 10.1016/j.jtho.2020.01.009
PMCID: PMC7202130

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