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Inflammatory Yet Restrained: Context-Dependent STING–Hypoxia Relationships Define Distinct Immune Ecosystems in Glioblastoma Across Bulk, Spatial, and Single-Cell Scales

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> The stimulator of interferon genes (STING) pathway is a critical mediator of innate immune activation and has emerged as a potential therapeutic target in oncology. Nevertheless, its precise biological and clinical significance in glioblastoma (GBM), particularly in the context of hypoxia and immune exhaustion, remains insufficiently characterized. <bold>Meth...

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Literature Corpus work: 92be2f55-3d63-58a9-9d5a-aa57039336b6
DOI: 10.21203/rs.3.rs-10720568/v1

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