Article

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

2018-12-02

Abstract excerpt

<h4>Summary</h4> The regulation of proliferation and polarity of neural progenitors is crucial for the development of the brain cortex, with modes and timings of cell division intimately related to the stereotypical acquisition of layer-specific neuronal identities. Animal studies have implicated glycogen synthase kinase 3 (GSK3) as a pivotal regulator of both proliferation and polarity, yet the functional releva...

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Literature Corpus work: 6327d157-b2f0-52cd-89c1-29bc8d4df760
DOI: 10.1101/484741

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