Article

Generation of human cerebral organoids with a structured outer subventricular zone

2023-02-17

Abstract excerpt

<h4>Summary</h4> Mammalian outer radial glia (oRG) emerge as cortical progenitor cells that directly support the development of an enlarged outer subventricular zone (oSVZ) and, in turn, the expansion of the neocortex. The in vitro generation of oRG is essential to model and investigate the underlying mechanisms of human neocortical development and expansion. By activating the STAT3 pathway using LIF, which is n...

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Literature Corpus work: 3941fa08-88c8-5311-a987-47305061d3f2
DOI: 10.1101/2023.02.17.528906

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