Article
Red blood cell tension protects against severe malaria in the Dantu blood group.
Nature - 1 Sept 2020
Kariuki Silvia N, Marin-Menendez Alejandro, Introini Viola, Ravenhill Benjamin J, Lin Yen-Chun, Macharia Alex, Makale Johnstone, Tendwa Metrine, Nyamu Wilfred, Kotar Jurij, Carrasquilla Manuela, Rowe J Alexandra, Rockett Kirk, Kwiatkowski Dominic, Weekes Michael P, Cicuta Pietro, Williams Thomas N, Rayner Julian C
Abstract excerpt
Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against all forms of severe malaria in homozygous individuals3-5, a similar degree of protection to that afforded by the sickle-cell trait and considerably greater than that...
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