Article

Alternative Splicing of MR1 regulates antigen presentation to MAIT cells

2019-07-11

Abstract excerpt

Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These cells are activated upon encountering microbial antigen(s) displayed by MR1 on the surface of an infected cell. Human MR1 undergoes alternative splicing. The full length isoform, MR1A, can activate MAIT cells, while the function of the isoforms, MR1B and MR1C, are not well characterized. In this repor...

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Literature Corpus work: 62e46e82-c4bc-57aa-b966-00ac970cc09f
DOI: 10.1101/695296

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