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Article

Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.

The Journal of biological chemistry - 3 Jun 2005

Huang Shouxiong, Gilfillan Susan, Cella Marina, Miley Michael J, Lantz Olivier, Lybarger Lonnie, Fremont Daved H, Hansen Ted H

Abstract excerpt

The novel class Ib molecule MR1 is highly conserved in mammals, particularly in its alpha1/alpha2 domains. Recent studies demonstrated that MR1 expression is required for development and expansion of a small population of T cells expressing an invariant T cell receptor (TCR) alpha chain called mucosal-associated invariant T (MAIT) cells. Despite these intriguing properties it has been difficult to determine...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15802267
DOI: 10.1074/jbc.M501087200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.PMID 15802267Read ↗

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteinsSemantic proximity Read ↗

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorSemantic proximity Read ↗

Alternative Splicing of MR1 regulates antigen presentation to MAIT cellsSemantic proximity Read ↗

Allelic variation alters expression and antigen presentation of MR1 allomorphs.Semantic proximity Read ↗

MAIT cell recognition of MR1 on bacterially infected and uninfected cells.Semantic proximity Read ↗

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries.Semantic proximity Read ↗

Diverse MR1-restricted T cells in mice and humansSemantic proximity Read ↗

MR1-Restricted T Cells Are Unprecedented Cancer Fighters.Semantic proximity Read ↗

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramersSemantic proximity Read ↗

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens.Semantic proximity Read ↗

A miniaturized MR1 metabolite display system with native-like protein featuresSemantic proximity Read ↗

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T CellsSemantic proximity Read ↗

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