Allelic variation alters expression and antigen presentation of MR1 allomorphs.

doi:10.1016/j.jbc.2026.111470

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Article

Allelic variation alters expression and antigen presentation of MR1 allomorphs.

The Journal of biological chemistry - 1 Jun 2026

Nelson Adam G, Letoga Victoria, Lee Clarice Z Q, Samer Carolyn, Li Songyi, Meehan Lucy J, McWilliam Hamish E G, Gherardin Nicholas A, Abendroth Allison, Villadangos Jose A, Slobedman Barry, Corbett Alexandra J, McCluskey James, Rossjohn Jamie, Chen Zhenjun, Souter Michael N T, Awad Wael

Abstract excerpt

The major histocompatibility complex (MHC) class I-related protein 1 (MR1) presents vitamin B-derived metabolites to mucosal-associated invariant T (MAIT) and other T cells. There is limited polymorphism of MR1, the functional impact of which is not understood. We examined the impact of allelic variation of MR1 on the expression, structure and function of the known MR1 allomorphs. The expression and function of...

Topics

Humans
Alleles
Histocompatibility Antigens Class I
Minor Histocompatibility Antigens
Antigen Presentation
Polymorphism, Genetic
Mucosal-Associated Invariant T Cells
Animals

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PMID: 42001947
DOI: 10.1016/j.jbc.2026.111470
PMCID: PMC13213668

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