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Article

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens.

The Journal of biological chemistry - 1 Apr 2026

Kulicke Corinna A, Lemon Chance, Krawic Jason R, Nieto Ramirez Luisa Maria, Kim Se-Jin, Narayanan Gitanjali, Tafesse Fikadu G, Hildebrand William H, Dobos Karen M, Lewinsohn David M

Abstract excerpt

The antigen presenting molecule major histocompatibility complex class I-related protein 1 (MR1) binds small molecule metabolites derived from the microbial riboflavin biosynthetic pathway and presents them at the cell surface for surveillance by MR1-restricted mucosal-associated invariant T cells (MAIT cells). MR1 ligands can originate in the extracellular space or in endosomal compartments that contain...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41759736
DOI: 10.1016/j.jbc.2026.111317
PMCID: PMC13022675

Genes

MR1
B2M

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens.PMID 41759736Read ↗

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Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigensSemantic proximity Read ↗

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T CellsSemantic proximity Read ↗

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cellsSemantic proximity Read ↗

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