Article

Activation and <i>in vivo</i> evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionality

2018-12-09

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer + cells derived from either human blood or murine lungs, we define the basic transcriptome of an activated MAIT cell in both species and demonstrate how this profile changes during resolution and reinfection phases of i...

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Literature Corpus work: 96a45786-0eea-5c95-b82f-cf1f1fa1dca9
DOI: 10.1101/490649

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