MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection.

doi:10.3389/fimmu.2021.631410

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MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection.

Frontiers in immunology - 1 Jan 2021

Khuzwayo Sharon, Mthembu Maphe, Meermeier Erin W, Prakadan Sanjay M, Kazer Samuel W, Bassett Thierry, Nyamande Kennedy, Khan Dilshaad Fakey, Maharaj Priya, Mitha Mohammed, Suleman Moosa, Mhlane Zoey, Ramjit Dirhona, Karim Farina, Shalek Alex K, Lewinsohn David M, Ndung'u Thumbi, Wong Emily B

Abstract excerpt

Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosal surfaces are often phenotypically and functionally distinct from those in the peripheral circulation, knowledge about the characteristics of MAIT cells at the lung...

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Identifiers

PMID: 33897687
DOI: 10.3389/fimmu.2021.631410
PMCID: PMC8062704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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