Article
Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases.
Prostate cancer and prostatic diseases - 1 Jun 2018
FitzGerald L M, Zhao S, Leonardson A, Geybels M S, Kolb S, Lin D W, Wright J L, Eeles R, Kote-Jarai Z, Govindasami K, Giles G G, Southey M C, Schleutker J, Tammela T L, Sipeky C, Penney K L, Stampfer M J, Gronberg H, Wiklund F, Stattin P, Hugosson J, Karyadi D M, Ostrander E A, Feng Z, Stanford J L
Abstract excerpt
BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. METHODS: Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort,...
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