Article

NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathway

2023-05-14

Abstract excerpt

<h4>Rationale</h4> The transcription factor NRF2 is well recognized as a master regulator of antioxidant responses and cytoprotective genes. Previous studies showed that NRF2 protects mouse hearts during chronic hemodynamic overload at least in part by reducing oxidative stress. Evidence from other tissues suggests that NRF2 may modulate glucose intermediary metabolism but whether NRF2 has such effects in the hea...

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Literature Corpus work: 6e2ad5e5-cabf-5915-930e-240282af9327
DOI: 10.1101/2023.05.12.540342

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