Article

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

2022-04-28

Abstract excerpt

Tumour cells from patients with chronic lymphocytic leukaemia (CLL) can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear to what extent these differences reflect the tumour cells’ innate pre/post germinal centre origin or their BCR s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62c3edce-f856-54f3-99cd-ea945a90bc08
DOI: 10.1101/2022.04.26.487675

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLLDOI 10.1101/2022.04.26.487675Read

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL.Semantic proximity Read

microRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters.Semantic proximity Read

Molecular pathogenesis of chronic lymphocytic leukemia.Semantic proximity Read

CLL Cells Respond to B-Cell Receptor Stimulation with a MicroRNA/mRNA Signature Associated with MYC Activation and Cell Cycle ProgressionSemantic proximity Read

Molecular pathogenesis of CLL and its evolution.Semantic proximity Read

Genetics and epigenetics of CLL.Semantic proximity Read

Systems Biology Analysis of DLK1-DIO3 Imprinted microRNAs Cluster in Chronic Lymphocytic LeukemiaSemantic proximity Read

Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLLSemantic proximity Read

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.Semantic proximity Read

Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance.Semantic proximity Read

Mutations driving CLL and their evolution in progression and relapse.Semantic proximity Read

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.Semantic proximity Read